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| Strengths/Mixed: (in D5W) |
| 1X: 1.5 mg/ml or 150 mg/ 100ml (LD soln) |
| 2X: 1.8 mg/ml or 360 mg/ 200 ml (MD soln) 2X: 1.8 mg.ml or 450 mg/ 250 ml (MD soln) |
| Recurrent VF: Hemodynamically Unstable VT: Cardiac Arrest: |
Recurrent VF |
| ADULT |
| LD: 150 mg over 10 min 2nd LD: 150 mg over 10 (if 150 mg bolus ineffective) MD#1: 1mg/min (33 mL/hr.) for 6 hours (360 mg over 6 hrs), MD#2: then 0.5 mg/min (16 mL/hr.) for 18 hours (540 mg over 18 hrs) MD#3: Transition to oral Cordarone |
| PEDI |
| Pulseless VT/SVT |
| 5 mg/kg up to 15 mg/kg IV/IO MAX Dose 300 mg |
| Pulsitile VT/SVT: |
| 5 mg/kg IV over 20-60 min up to 15 mg/kg MAX 300 mg |
| Atrial Fibrillation Prophylaxis w Heart Surgery |
| ADULT |
| 150-300 mg IV x 1 intraop (off label) |
| Myocardial Infarction: |
| ADULT |
| 200-400 mg IV q d (off label) |
| Supraventricular Arrythmia Rx and Px: |
| ADULT |
| Rate Control: 300 mg IV over 1 hour then - 10-50 mg/hr IV x 24 hrs Pharmacologic Cardioversion: 150 mg IV over 10 min, 1 mg/min IV x 6 hrs, then 0.5 mg/min IV x 18 hrs |
| NSR maintenance after AF: 150 mg IV over 10 min, 1 mg/min IV x 6 hrs, then 0.5 mg/min IV x 18 hrs (consider reducing dose to 0.25 mg/min) |
| PEDI |
| 5 mg/kg IV over 20-60 min up to 15 mg/kg MAX 300 mg MD: 5-15 mcg/kg/min IV (7-20 mcgkg/day) MAX Dose: 2025 mcg/kg/min (29-36 mg/kg/d) 3 days Max |
| Postop SVT: 5 mg/kg IV over 1-4 hours MD: 7-21 mcg/kg/d OR repeat bolus 1-2 times OR 20 mg/kg/day until rate control |
| Baseline Studies: |
| CXR,PFTs,Thyroid Function tests, Liver Panelm, K+, Ca++, Mg++ |
| t1/2 53 days Hypotension Bradycardia Proarrhythmic Events Peripheral Neuropathy Thyroid Dysfunction Thyroid storm, Nausea, Vomiting, Pulmonary toxicity Administer via CVP with in-line filter Contraindicated in Pregnancy unless last line Rx Monitor QT interval |
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